N-Methyl D-aspartate receptor subunit signaling in fear extinction
نویسندگان
چکیده
منابع مشابه
Combined Therapy for Anti-N-methyl D-aspartate Receptor Encephalitis
Background Anti-N-methyl- d-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune neurological disorder that usually occurs as a paraneoplastic syndrome and is particularly associated with ovarian teratoma. Standard therapy for severe cases is not established and the prognosis in patients who do not respond to first-line treatment is poor. Case Report An 11-year-old boy complained ps...
متن کاملmodulation of nr1 subunit of n-methyl-d-aspartate receptor by ovariectomy and passive avoidance learning.
background: learning and memory are the most intensively studied subjects in neuroscience. two sites of mammalian brain which are important in learning and memory are ca1 region of hippocampus and purkinje cell layer of cerebellum. so, the aim of present investigation was to study of the effect of ovariectomy and passive avoidance learning on nr1 subunit of n-methyl-d-aspartate (nmda) receptor ...
متن کاملMechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators.
The compound 4-(5-(4-bromophenyl)-3-(6-methyl-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid (DQP-1105) is a representative member of a new class of N-methyl-d-aspartate (NMDA) receptor antagonists. DQP-1105 inhibited GluN2C- and GluN2D-containing receptors with IC(50) values that were at least 50-fold lower than those for recombinant GluN2A-, GluN2B-, ...
متن کاملThe Role of the N-Methyl-D-Aspartate Receptor (NMDAR) – NR2b Subunit in Female Reproductive Aging
The loss of reproductive capacity during aging involves changes in the neural regulation of the hypothalamic gonadotropin-releasing hormone (GnRH) neurons controlling reproduction. This neuronal circuitry includes glutamatergic receptors on GnRH neurons. Previously, the Gore lab reported an increase in the expression of the NR2b subunit protein of the NMDA receptor on GnRH neurons in middle-age...
متن کاملN-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning.
The role of N-methyl-D-aspartate (NMDA) receptors in Pavlovian fear conditioning was examined using the NMDA antagonist DL-2-amino-5-phosphonovaleric acid (APV). Either APV (5 micrograms/rat) or saline was administered before the training phase, the testing phase, or both. APV completely blocked acquisition but not expression of fear conditioning. The L enantiomer of APV did not affect the acqu...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2018
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-018-5022-5